-1- SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS

摘要

The present invention relates to hypertension (including malignant hypertension), laryngitis, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, arrhythmias, cardiomyopathy (including hypertrophic cardiomyopathy), heart failure, heart attack. , bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolism, pulmonary hypertension, mesothelioma, ventricular conduction abnormality, complete heart block, adult respiratory distress syndrome, sepsis syndrome, idiopathic lung Provided are compounds effective as sphingosine-1-phosphate receptor modulators for the treatment of cardiopulmonary diseases, such as fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.