Deimmunized Shiga toxin A subunit effector polypeptide for mammalian application

摘要

PROBLEM TO BE SOLVED: To provide an improved Shiga toxin A subunit-derived polypeptide having sufficient antigenicity and / or immunogenicity, which retains sufficient Shiga toxin effector function for medical application. SOLUTION: The Shiga toxin effector region comprises disruption of at least one epitope region of the Shiga toxin A subunit amino acid sequence selected from a group of naturally occurring amino acid residues by substituting a specific amino acid. Provided is a polypeptide in which the region can exhibit Shiga toxin effector function. [Selection diagram] Fig. 1