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COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION
COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION
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机译:用于抑制HMGB1表达的组合物和方法
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摘要
This disclosure relates to oligonucleotides, compositions and methods useful for reducing HMGB1 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of HMGB1 expression may be either double-stranded or single-stranded and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of HMGB1 expression may also be designed to include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat liver fibrosis and related conditions.
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