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A pharmaceutical composition for treating a disease by inhibiting D-amino acid oxidase (DAAO).
A pharmaceutical composition for treating a disease by inhibiting D-amino acid oxidase (DAAO).
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机译:通过抑制D-氨基酸氧化酶(DAAO)治疗疾病的药物组合物。
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摘要
The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy-drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.
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