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SACUBITRIL VALSARTAN CALCIUM SALT COMPOSITE AND METHOD FOR MANUFACTURING THE SAME
SACUBITRIL VALSARTAN CALCIUM SALT COMPOSITE AND METHOD FOR MANUFACTURING THE SAME
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机译:Sacubitril Valsartan钙盐复合材料及其制造方法
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摘要
The present invention relates to a sacubitril valsartan calcium salt complex usable as a pharmaceutical ingredient and a method for preparing the same, and more particularly, to a mixture prepared through a valsartan dissolution step of dissolving valsartan in a solvent, which is amorphous, and the valsartan dissolution step. Sacubitril calcium salt mixing step of mixing Sacubitril calcium salt and heating and stirring, filtration and concentration step of filtering and concentrating the mixture prepared through the Sacubitril calcium salt mixing step to obtain a solid content, and the filter concentration step It is prepared through a drying step of pulverizing and drying the solid content obtained through the The sacubitril valsartan calcium salt complex and its manufacturing method show excellent economic feasibility by manufacturing the sacubitril valsartan calcium salt complex excellent in stability, hygroscopicity, solubility and solid fluidity through a simple process.
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