NN--p- Composition for preventing improving or treating Alzheimer's disease comprising NN-Diacetyl-p-phenylenediamine as an active ingredient

摘要

The present invention relates to a composition for preventing, improving or treating Alzheimer's disease, comprising a N,N'-diacetyl-p-phenylenediamine (N,N'-Diacetyl-p-phenylenediamine; DAPPD) compound as an active ingredient. According to the present invention, it was confirmed that the DAPPD compound effectively ameliorated cognitive deficits by promoting the removal of amyloid-beta species by restoring the impaired phagocytic function of microglia in an experiment using Alzheimer's disease transgenic mice. has a very small and simple structure, passes through the blood-brain barrier (BBB) and is absorbed into the brain and has little toxicity. It is expected to be used as a promising therapeutic agent for neurodegenerative diseases, specifically Alzheimer's disease.