Composition and method for treating pathological calcification and ossification

摘要

Problem to be solved: to provide a method for treating diseases and disorders associated with pathological calcification or pathological ossification.Econucleotide pyrophosphate / phosphodiesterase-1 (NPP1) polypeptide and its fragments, derivatives, variants, or mutant fragments, and NPP1 polypeptides and their fragments, mutants Or a method of administering a composition comprising at least one active substance selected from the group consisting of the activating factor of the mutant fragment.Preferably, the NPP1 polypeptide or its fragment, variant or mutant fragment is a soluble recombinant NPP1 polypeptide or its fragment, variant, or mutant fragment.Diagram