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PRO-ADRENOMEDULLIN OR FRAGMENT THEREOF IN PATIENTS INFECTED WITH CORONA VIRUS AND TREATMENTS WITH BINDER AGAINST ADRENOMEDULLIN
PRO-ADRENOMEDULLIN OR FRAGMENT THEREOF IN PATIENTS INFECTED WITH CORONA VIRUS AND TREATMENTS WITH BINDER AGAINST ADRENOMEDULLIN
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机译:促进肾上腺素细胞素或其片段,患者用电晕病毒和粘合剂对抗肾上腺髓素治疗
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摘要
Subject matter of the present invention is a method for (a) diagnosing or predicting the risk of life-threatening deterioration or an adverse event or (b) prognosing the severity or (c) predicting or monitoring the success of a therapy or intervention in a patient infected with a Corona virus, the method comprising: - determining the level of pro-Adrenomedullin (SEQ ID No. 31) or fragment thereof in a sample of bodily fluid of said patient, - comparing said level of pro-Adrenomedullin or fragment thereof to a pre- determined threshold or a previous level of pro-Adrenomedullin or fragment thereof, and - correlating said level of pro-Adrenomedullin or fragment thereof with the risk of life-threatening deterioration or an adverse event, or - correlating said level of pro-Adrenomedullin or fragment thereof with the severity, or - correlating said level of pro-Adrenomedullin or fragment thereof with the success of a therapy or intervention, wherein said pro-Adrenomedullin or fragment thereof is selected from the group consisting of PAMP (SEQ ID No. 32), MR-proADM (SEQ ID No. 33), ADM-NH2 (SEQ ID No. 20), ADM- Gly (SEQ ID No. 21) and CT-proADM (SEQ ID No. 34). Subject matter of the present invention is an Anti-adrenomedullin (ADM) antibody or anti- ADM antibody fragment or anti-ADM non-Ig scaffold for use in therapy or intervention in a patient in a patient infected with a Corona virus.
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机译:本发明的主题是(a)诊断或预测危及生命的恶化或不良事件或(b)预测或监测治疗或干预的侵害成功的危及生命恶化或不良事件或(b)的方法患者用电晕病毒感染,该方法包括: - 确定所述患者的体液样品中的促肾上腺素(SEQ ID No.31)或其片段的水平 - 比较所述促肾上腺素细胞素或其片段预定阈值或先前水平的亲肾上腺素细胞蛋白或其片段,以及与危及生命的恶化或不良事件的风险相关,或者与不良事件的风险相关,或者 - 关联所述水平 - 肾上腺素或其片段具有严重程度,或 - 将所述水平与治疗或干预的成功相关,或者将所述水平与其介入的成功相关,其中所述促肾上腺素或其中片段F选自PAMP(SEQ ID No.32),MR-Proadm(SEQ ID No.33),ADM-NH2(SEQ ID No.20),ADM-(SEQ ID No.21)和CT-Proadm(SEQ ID No.34)。本发明的主题是一种抗肾上腺细胞蛋白(ADM)抗体或抗ADM抗体片段或抗ADM非IG支架,用于治疗或干预患者在感染的患者中感染珊瑚病毒。
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