A tool and method for controlling cell proliferation using a cell division locus

摘要

The present disclosure provides molecular tools, methods and kits for controlling cell growth in animal cells using the cell division locus (CDL). The CDL provided herein is a genetic locus where the transcript is expressed during cell division. CDL can be genetically modified to include a gene expression system based on negative selectable markers and / or inducible activators, as described herein, which allows the user to add appropriate inducers or Removal can allow, ablate and / or inhibit the growth of genetically modified cells. [Selection] Figure 2