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COMPOSITIONS, METHODS, AND SYSTEMS FOR GENOME EDITING TECHNOLOGY
COMPOSITIONS, METHODS, AND SYSTEMS FOR GENOME EDITING TECHNOLOGY
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机译:基因组编辑技术的组合物,方法和系统
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摘要
The present disclosure provides compositions, methods, and systems related to genome editing technology. In particular, the present disclosure provides a novel CRISPR-based genome editing technology that involves the generation of abasic sites to facilitate genetic recombination, without the need for breaks in the DNA. The compositions, methods, and systems described herein address many of the drawbacks of currently available approaches, including off-target effects and cellular toxicity.
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