Fc binding protein with enhanced stability to heat, method for producing said protein and antibody adsorbent using the protein

摘要

Problem to be solved: to provide a Fc binding protein capable of improving stability to heat for a natural type human FcRn, a method of producing the protein, and an antibody adsorbent using the protein.Natural type human FcRn α The extracellular region and human FcRn of the amino acid sequence (UniProt No. p55899) in the chain β In the amino acid sequence of the chain β 2 at least including the microglobulin regionHowever, an Fc binding protein that has amino acid residues in the region replaced at least a specific amino acid at a particular site is substituted and / or lostMethod for producing said proteinAnd by an antibody adsorbent using the proteinThe above problem is solved.Diagram