Method and composition for killing senescent cells and treating aging related diseases and disorders

摘要

Problem to be solved: to provide a method for selectively killing a senescent cell and treating a disease related disease or disorder by administration of a senescent cell destruction agent.By the administration of the aging cell destruction drug, it is associated with arteriosclerosis such as atherosclerosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, osteoarthritis, eye disease and disorder related to aging, and skin disease or disorder related to aging or Treat the disease or disorder of the heart caused by these.Aging cell destruction drug is an MDM2 inhibitor; Inhibitors of one or more Bcl-2 anti apoptotic protein family members that inhibit at least BCL XL; And selected from Akt specific inhibitors.Diagram