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Formulation, preparation method and galenesis preparation for intestinal release of digestive enzyme
Formulation, preparation method and galenesis preparation for intestinal release of digestive enzyme
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机译:消化酶肠道释放的制剂,制备方法和Galeanis Arthect
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摘要
The present invention is a formulation of at least one digestive enzyme, wherein the formulation comprises solid lipid particlesSolid lipid particles- size μ M to 1200 μ AndStrictly hydrophobic, andContaining no water, organic solvents, surfactant compounds and polymersAt least one digestive enzymeContains a strictly hydrophobic, non hygroscopic wax matrixAt least one digestive enzymeUniformly distributed in each solid lipid particle of the formulation- distributed without distribution gradients toward the interior of the wax matrix.- accounted for 0.1% to 90% of the mass of the formulationThe melting point of the formulation is between 20 andIt relates to pharmaceutical preparations.No selection
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