INHIBITION OF ALTERNATIVE COMPLEMENT PATHWAY FOR TREATMENT OF RETINAL ISCHEMIC INJURY AND GLAUCOMA

摘要

Described herein are methods and compositions for reducing or inhibiting retinal cell death in a subject comprising retinal ischemic injury. The method comprises administering to an ischemic retinal tissue of the subject a composition comprising an agent that inhibits or reduces alternative complement pathway activity to reduce or inhibit complement-mediated retinal, neuronal, or retinal neuronal cell death during disease or injury.