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METHOD OF PREDICTING THE LIKELIHOOD OF SUCCESS OF GENE THERAPY
METHOD OF PREDICTING THE LIKELIHOOD OF SUCCESS OF GENE THERAPY
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机译:预测基因治疗成功可能性的方法
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摘要
A method of predicting the likelihood of success of a gene therapy procedure includes inducing DNA damage in a cell sample from an individual. The ability of the individual's cells in the sample to repair the DNA damage is then assessed to determine whether the individual could tolerate DNA damage caused by a gene therapy vector. In preferred embodiments, the ability of the individual's cells to repair DNA damage is assessed by detecting, and monitoring the subsequent disappearance of, a marker of DNA damage repair (such as gamma H2AX or phosphorylated 53BP1) in the sample.
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