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Methods of identifying agents having neuroprotective or anti-oxidant activity for regulating mitochondrial function
Methods of identifying agents having neuroprotective or anti-oxidant activity for regulating mitochondrial function
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机译:用于调节线粒体功能的具有神经保护或抗氧化活性的药剂的鉴定方法
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摘要
A method for assessing whether a test substance or treatment is potentially neuroprotective or anti-oxidant, the method comprising the steps of exposing a cell to the test substance or treatment assessing the TSPO level in the cell, wherein a substance or treatment is considered to be potentially anti-oxidant and/or neuroprotective if the TSPO level is decreased. The method may comprise the step of assessing the level of mitophagy in the cell, wherein a substance or treatment is considered to be anti-oxidant or neuroprotective if the level or induction of mitophagy is increased and the TSPO level is decreased.
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