NON-INVASIVE SUCCESSFULNESS TEST OF IN VITRO FERTILIZATION PROCESS

摘要

It comprises two independent steps: the step of identification and analysis of the prognostic canonical and iso-miRNA biomarkers from women's peripheral blood plasma on the day of the IVF process – the Success Test; and the step of prognostic canonical miRNA and iso-miRNA biomarkers from a spent blastocyst medium collected once on day 4 to 6 of the embryo's cultivation – the CultMed Test; wherein the successful Success Test shows the cut off values of the selected miRNA biomarkers at reads number of 1 being ≥ 1, and the cut off value of miRNA iso-hsa-let-7b-5p_TGAGGTAGTATGTTGTGTGG at reads number of 5 being ≥ 5, and the successful CultMed Test shows the cut off value of the selected miRNA biomarkers at reads number of 1 being ≥ 1; and wherein said values in both tests predict the successful invitro fertilization process.