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INJECTABLE BOTULINUM TOXIN FORMULATIONS AND METHODS OF USE THEREOF HAVING HIGH RESPONSE RATE AND LONG EFFECT DURATION
INJECTABLE BOTULINUM TOXIN FORMULATIONS AND METHODS OF USE THEREOF HAVING HIGH RESPONSE RATE AND LONG EFFECT DURATION
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机译:可注射肉毒杆菌毒素制剂及其使用方法具有高响应速率和长效持续时间
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摘要
This invention provides injectable compositions comprising botulinum toxin that may be administered to a subject for various therapeutic, aesthetic and/or cosmetic purposes. The injectable compositions embraced by the invention exhibit one or more advantages over conventional botulinum toxin formulations, including reduced antigenicity, a reduced tendency to undergo unwanted localized diffusion following injection, increased duration of clinical efficacy or enhanced potency, higher responder rates, faster onset of clinical efficacy, and/or improved stability. According to the invention, single treatment of the compositions by injection affords significant clinical responses and at least a 26-week duration of effect in a subject undergoing treatment, as provided by the described treatment methods, as well as still higher responder rates and/or longer duration of effect following subsequent treatments.
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