4-PYRROLIDIN-1-YL-5-P-TOLYL-THIENO2,3-D PYRIMIDINE FOR USE IN THE TREATMENT OF AGING-ASSOCIATED AND PREMATURE AGING DISEASES THROUGH RESTORED CHROMOSOMAL STABILITY AND INHIBITION OF CELLULAR SENESCENCE

摘要

The present invention refers to the use of a small molecule to inhibit cellular hallmarks of aging, with therapeutic impact in aging-associated diseases and progeroid syndromes.The present invention discloses that defective mitotic mechanisms contribute to age-associated chromosomal instability(CIN) and to cell senescence. In particular, the present invention discloses that dysfunction of microtubule dynamics arising with age due to decreased MT-depolymerizing kinesin-13 activity, mildly perturbs genomic stability and contributes to the generation of fully senescent cells. Importantly, chromosomal stability in old-aged cells is restored upon the use of a small molecule to enhance MT-depolymerizing kinesin-13.Therefore, the present invention refers to 4-Pyrrolidin-1-Yl-5-P-Tolyl-Thieno[2,3-D]Pyrimidine substances or compositions, and any of its derivatives, for use in the treatment of ageing associated diseases, through restored chromosomal stability and inhibition of the phenotypes of cellular senescence.The present invention also refers to 4-Pyrrolidin-1-Yl-5-P-Tolyl-Thieno[2,3-D]Pyrimidine substances or compositions, and any of its derivatives, for use in the treatment of premature aging diseases.