Paracetamol: a fixed dose composition of amitriptyline and method for treating mixed cancer pain

摘要

The present invention relates to the medicinal composition of paracetamol, and particularly amitriptyline, which has been demonstrated by pharmacological interactions, as well as the anti allodynia action, the mechanical antihypersensitivity and the reduction of sustained pain Safety studies demonstrate synergy for safety and neuroprotection.It is intended to treat mixed pain caused by cancer, and can be introduced as another option for the strategy of who pain analgey ladder in the first stage for the treatment of mild pain.However, this can also be included in higher order stages associated with opioids for treatment of greater intensity pain, potentially reducing the detrimental effects of dose increment and tolerance and hyperalgesia.