EXTRACELLULAR VESICLES FOR THE TREATMENT AND PREVENTION OF INFECTIONS AND OTHER DISEASES

摘要

In various embodiments, drug-loaded extracellular vesicles and methods of making the same are disclosed. In various embodiments, the EVs comprise natural exosomes or exomeres derived from cells that take part in the pathogenesis of a disease or a condition to which the drug-loaded EVs are targeted. In various embodiments, extracellular vesicles are surface modified, comprising bound biomolecules such as proteins or antibodies that can target ACE2 receptors. Surface modified EVs find use in the treatment and prevention of viral infections, such as COVID-19 caused by a SARS-CoV-2 infection in a human individual.