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POSACONAZOLE INTRAVENOUS SOLUTION FORMULATIONS STABILIZED BY SUBSTITUTED BETA-CYCLODEXTRIN

机译：取代的β-环糊精稳定的波萨克唑静脉内溶液配方

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摘要

The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified β-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.

机译：本发明涉及水性溶液，可用作posaconazole的药物组合物用于静脉内给药。这些组合物包括溶解剂的增溶剂，例如酸化溶液中的改性β-环糊精，其还可包括螯合剂如乙酸二钠（EDTA）。在临床试验中，发现了200mg posaconazole剂量的选定组合物达到可接受的药代动力学性能。

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公开/公告号EP3391890B1

专利类型
公开/公告日2021-08-25

原文格式PDF
申请/专利权人
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申请/专利号EP20180171672
发明设计人 HEIMBECHER SUSAN K.;MONTEITH DAVID;
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申请日2011-06-24
分类号A61K31/715;A61K31/497;A61P31;A61P31/10;A61K31/496;A61K9;A61K31/724;A61K47/40;A61P3/06;A61P7/02;A61P31/04;A61P33;A61P33/02;A61P35;A61P35/02;A61P35/04;A61P37/06;A61P7/04;A61P31/08;A61P31/18;
国家 EP
入库时间 2022-08-24 20:47:10

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