PURINE DERIVATIVES AS TLR7 INHIBITORS FOR TREATING E.G. SYSTEMIC LUPUS ERYTHEMATOSUS

摘要

The present invention relates to a substituted purine derivative of formula (1) wherein R 1 is alkoxy or the like, R 2 is alkyl or the like, Ring Q 1 is aryl or the like, W 1 is alkylene or the like, Ring Q 2 is aromatic carbocyclyl or the like, n is 1 - 4, R 3 is hydrogen atom or the like, X 1 is single bond or the like, W 2 is alkylene or the like, and R 4 is hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease.