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ANTI-CD45-BASED CONDITIONING PROCEDURES AND THEIR USES IN CONNECTION WITH APPROVED SELF-BASED THERAPIES
ANTI-CD45-BASED CONDITIONING PROCEDURES AND THEIR USES IN CONNECTION WITH APPROVED SELF-BASED THERAPIES
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机译:基于验证自基疗法的基于反CD45的调理程序及其用途
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摘要
This invention provides a method for depleting a subject's immune cells, where the method includes administering to the subject an effective amount of a radiolabeled anti-CD45 antibody. This invention also provides a method for treating a subject afflicted with cancer, where the method includes (i) administering to the subject an amount of a radiolabeled anti-CD45 antibody effective to deplete the subject's lymphocytes, and (ii) after a suitable time period, performing adoptive cell therapy on the subject to treat the subject's cancer. Finally, this invention provides an article of manufacture including (a) a radiolabeled anti-CD45 antibody, and (b) a label instructing the user to administer to a subject an amount of the antibody effective to deplete the subject's immune cells.
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