METHOD FOR THE IDENTIFICATION OF CARDIAC FIBRILLATION DRIVERS AND/OR THE FOOTPRINT OF ROTATIONAL ACTIVATIONS USING SINGLE OPTICAL OR ELECTRICAL SIGNALS WITHOUT REQUIRING PANORAMIC SIMULTANEOUS ACQUISITION

摘要

This invention relates toex vivomethods and uses, medical apparatus and related computer program and computer-readable medium for the determination of ablation sites for ablation treatments applied to cardiac tissue.In particular, it relates to anex vivo (outside of the human or animal body)use of the instantaneous frequency modulation (iFM) signal calculated as the reciprocal of the intervals between consecutive cardiac activations during cardiac fibrillation, wherein said activations are obtained from i) a single or multiple electrical unipolar signals obtained via a single or multiple mapping electrodes, or ii) a single or multiple optical signals obtained via a single or multiple optical fibers, wherein preferably the spatial locations at the times of acquisition are used for constructing an electroanatomical map of the heart in a subject in need thereof, for detecting 'driver' or 'high-hierarchy' regions in the heart of a subject with cardiac fibrillation.