TRIAZOLES FOR REGULATION OF INTRACELLULAR CALCIUM HOMEOSTASIS

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a compound of formula (I), in which R¹ is C_1-4 alkylene biradical; R² is C_1-4 alkylene biradical optionally substituted with one or two substituents independently selected from a group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, second-butyl, tert-butyl, 3-aminopropyl, 4-aminobutyl, benzyl, 4-hydroxybenzyl; R³ is H; m is selected from 0, 1, 2 and 4; n is selected from 0, 1 and 2; X is independently selected from a group consisting of O(C_1-4 alkyl), C_1-6 alkyl, CF₃ and halogen; and Y is selected from a group consisting of -CO₂H, -CO₂(C_1-4 alkyl), - N(C_1-4 alkyl)₂, or its pharmacologically acceptable stereoisomer or salt. The invention also relates to a pharmaceutical composition and applications of the compound of formula (I). ;EFFECT: new compounds of formula (I) are obtained that can be used for the treatment and/or prevention of disorders or diseases associated with a disruption of the regulation of intracellular calcium or RyR receptor dysfunction.; (I);19 cl, 8 dwg, 1 tbl, 27 ex