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Cannabinoid composition and method of sublingual, buccal and oral mucosa delivery

机译:大麻组合物和舌下,口腔粘膜递送的方法

摘要

A formulation includes a cannabinoid extract that is pharmaceutically effective by systemic delivery via a recipient's oral mucosal lining. The method of delivery avoids the digestive tract processing and liver metabolizing of the active ingredients of the formulation, whereby lower doses cause a desired therapeutic effect or other intended effect. Variations of the formulation include a cannabinoid extract and one or more of pregelatinized tapioca starch polymethylsilsesquioxane, bromelain, volume Fenugreek gum, vitamin B12, luo han guo fruit extract, mannitol, microcrystalline cellulose, sodium alginate, gellan gum, menthol Natural peppermint flavor or oil, Grapefruit flavored powder or oil, magnesium stearate and/or citric acid. The cannabinoid extract may include Tetrahydrocannabinol, tetrahydrocannabinolic acid, Cannabidiol, Cannabidiol acid, and/or other cannabinoid sourced from a Cannabis sativa plant. The formulation includes at least one cannabinoid in a volume and measure that is pharmaceutically effective and/or effectual in achieving an intended systemic state or response of the recipient.
机译:制剂包括通过受体的口腔粘膜衬里通过全身递送来药学有效的大麻素提取物。递送方法避免了消化道处理和肝脏对制剂的活性成分的肝脏代谢,由此较低剂量会导致所需的治疗效果或其他预期的效果。制剂的变化包括大麻素提取物和一种或多种预胶质化烟草淀粉聚合物,溴素,体积春瓜蛋白,维生素B12,罗汉国果提取物,甘露醇,微晶纤维素,海藻酸钠,Gellan Gum,薄荷醇天然薄荷味或油,葡萄柚调味粉或油,硬脂酸镁和/或柠檬酸。大麻素提取物可包括四氢甘油基酚,四氢甘油糖醇,大麻,大麻酸和/或来自来自大麻苜蓿植物的其他大麻素。制剂包括体积和测量中的至少一个大麻素,其在获得预期的系统状态或接受者的响应方面是药学上有效和/或有效的。

著录项

  • 公开/公告号US11090346B2

    专利类型

  • 公开/公告日2021-08-17

    原文格式PDF

  • 申请/专利权人 INBOLD INC.;

    申请/专利号US201916424351

  • 发明设计人 KENDA HANSEN;KATHLEEN GRAVE;

    申请日2019-05-28

  • 分类号A61K36/185;A61K47/36;A61K31/714;A61K38/48;A61K47/46;A61K47/26;A61K47/12;A61K31/05;A61K9;A61K31/192;A61K31/352;A61K47/38;

  • 国家 US

  • 入库时间 2022-08-24 20:38:09

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