A chitosan/TEMPO oxidized cellulose nanofiber hydrogel comprising fk506 for bone therapy and a method for manufacturing the same

摘要

Chitosan / tempo oxidized cellulose nanofiber hydrogel containing fk506 for bone treatment according to an embodiment of the present invention, fk506, chitosan, a gelling agent, and tempo oxidized cellulose nanofibers. When using the method for producing a chitosan/tempo-oxidized cellulose nanofiber hydrogel containing fk506 for bone treatment according to the present invention, the NaHCO ₃ content is high, so the sol/gel transition rate increases and the decomposition rate of the CS/TOCNF hydrogel has the effect of lowering In addition, even at a low concentration of fk506, 5 nM, it has the effect of inducing the growth and differentiation of MC3T3-E1 cells, which are progenitor osteoblasts, in vitro (2D culture), so it can be introduced into CS/TOCNF hydrogels, and can be introduced into bone in vivo. There is an advantage that bone regeneration can be induced by introducing a CS/TOCNF hydrogel containing fk506 into the defect site.