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MICROFLUIDIC DEVICE WITH INTERFACE PINNING REACTION VESSELS WITHIN A FLOW-THROUGH CHAMBER, KIT FOR FORMING, AND USE OF SAME
MICROFLUIDIC DEVICE WITH INTERFACE PINNING REACTION VESSELS WITHIN A FLOW-THROUGH CHAMBER, KIT FOR FORMING, AND USE OF SAME
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机译:微流体装置,具有界面钉扎反应容器在流通腔室内,用于形成的套件,以及使用
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摘要
A technique for detection of probes in a microfluidic flow-through chamber involves a plurality of interface pinning reaction vessel formed by micro- or nano-structured relief patterning of a substrate. The relief patterning increases a surface area locally, and defines a plurality of separated interface pinning reaction vessels. The marked detection protocol may be supplied on a single layer of a stacked microfluidic chip, or the chamber may constitute a whole layer. The chip may be designed to be driven mechanically, pneumatically, hydraulically, centrifugally or by capillary action. Each vessel allows for a high density of probes, an effective region for developer-type or fluorescence-based marking, and efficient readout. Suitable probe liquids can be self-limiting to fill one vessel. Suitable developer liquids avoid dye bleeding across vessels during washing.
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