Method and composition for prolonging survival after orthotopic and ectopic heterotopic heart, kidney, lung or liver transplantation

摘要

The present invention provides a method for prolonging the survival of primates derived from genetically modified hearts, kidneys, lungs or liver derived from different mammals in life support techniques, and genetically modified heart, kidney, derived from different mammals in life support techniques The present invention relates to a composition for use in a method of prolonging the survival of primates with lung or liver transplants.The present invention also contemplates a living primate having heart, kidney, lungs or liver functionally replaced by genetically modified heart, kidney, lungs or liver derived from transplanted heterologous mammals.Finally, the present invention is directed to donor organisms of genetically modified mammals and heterologous organ transplants and methods for producing them.