METHODS UTILIZING LEUKOCYTE RNA EXPRESSION IN PROGNOSIS EVALUATION OF MEDICAL INTERVENTIONS FOR EPILEPSY

摘要

Methods involving analysis of pretreatment leukocyte expression profiles for prognostic assessment of seizure outcome following a treatment or medical procedure, such as stereotactic laser amygdalohippocampotomy (SLAH). In one aspect, RNA sequencing (RNA-Seq) on whole blood leukocyte samples is taken from a patient with intractable epilepsy prior to SLAH. Differential expression (DE) analysis revealed 24 significantly dysregulated genes (≥2.0-fold change, p-value<0.05, and False Discovery Rate, FDR<0.05) useful in prognostic assessment.