Nanovesicles derived from Rothia bacteria and Use thereof

摘要

The present invention relates to a vesicle derived from a bacterium of the genus Rocia and its use, and the present inventors compared the clinical samples of patients with diabetes, atrial fibrillation, cardiomyopathy, liver cancer, cirrhosis, dementia, depression, Parkinson's disease, and atopic dermatitis compared to normal persons. Vesicles are significantly reduced, and when the vesicles isolated from the above strains are administered, the secretion of inflammatory mediators by pathogenic vesicles such as E. coli vesicles is significantly suppressed, and the vesicles derived from bacteria of the genus Rochia are damaged by stress hormones. As it was confirmed experimentally that significant inhibition It is expected to be usefully used for the purpose of developing a composition for preventing or treating cardiovascular disease, liver disease, cranial nerve disease, and inflammatory disease.