NEW ANTIMICROBIAL COMPOUNDS, THEIR USE FOR TREATMENT OF MAMMALIAN INFECTIONS AND NEW METABOLIC MECHANISM

摘要

FIELD: veterinary medicine.;SUBSTANCE: invention relates to a compound selected from (S)-7-Methyl-2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]decane-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazine-4-one, (S)-5-Methyl-2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]decane-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazine-4-one and 2-(4-(Cyclohexylmethyl)piperazine-1-yl)-5-methyl-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazine-4-one, which has activity against Mycobacterium tuberculosis H37Rv and (PDR) 12700, M. Marinum, M. Vaccae 10670 strains, pharmaceutical compositions based on them and their use for the therapeutic or preventive treatment of mycobacterial infection in mammals. ;EFFECT: obtaining compounds for treatment of mammalian infections.;4 cl, 4 dwg, 1 tbl, 17 ex