METHOD FOR RETAINING SPLICING RNAS IN THE NUCLEUS BASED ON CHEMICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES

摘要

The inventive technology relates to systems and methods for the use of chemically modified antisense oligonucleotides (ASOs) to sterically prevent intron excision thus causing nuclear retention of the RNA and inhibiting nuclear export. In preferred therapeutic embodiments, ASOs may be engineered to quarantine clinically relevant RNAs in the nucleus of the cell.