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BIORESORBABLE IMPLANT WITH INSIDE-OUT RESORPTION FOR ENHANCED BONE INGROWTH AND TISSUE INTEGRATION AND METHOD OF MANUFACTURING THEREOF
BIORESORBABLE IMPLANT WITH INSIDE-OUT RESORPTION FOR ENHANCED BONE INGROWTH AND TISSUE INTEGRATION AND METHOD OF MANUFACTURING THEREOF
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机译:具有内部吸收的可生物可吸收植入物,用于增强骨骼的骨骼和组织集成及其制造方法
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摘要
Disclosed is a bioresorbable implant with enhanced bone ingrowth and tissue integration utilizing an inside-out resorption mechanism and a method to manufacture a bioresorbable implants for use in osteotomies and bone-soft tissue reconstruction surgeries. The bioresorbable implant includes a polymer A (e.g., an aliphatic polymer matrix) and/or poly(propylene fumarate)), a carbohydrate B (e.g., a bioresorbable natural carbohydrate filler) and a ceramic C. The implant may be a porous scaffold structures with suitable porosity, pore size, pore interconnectivity, and mechanical properties for enhanced osteoblast penetration and bone formation to fabricate tissue integrating bioresorbable implants. The implant may be shaped as wedges, bone void fillers, and soft tissue fixation implant like screws, rods and/or anchors. In some embodiments, the implant may be a putty.
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