Lung delivery of mRNA to non lung target cells

摘要

To provide pulmonary delivery of mRNA to non-lung target cells.SOLUTION: The invention provides compositions comprising mRNA formulated for pulmonary administration and related methods for delivery of the mRNA and/or encoded protein to a non-lung cell or tissue. The compositions and methods may be used to prevent or ameliorate symptoms of diseases associated with the mRNA encoded protein. Thus, the present invention provides methods for delivery of mRNA gene therapeutic agents using non-invasive pulmonary administrations. Among other things, the present invention provides for delivery of mRNA encoding a protein, which can be used in a method for treating and/or preventing a disease.SELECTED DRAWING: Figure 12