Diagnostic methods for Parkinson's disease through bacterial metagenome analysis

摘要

The present invention relates to a method for diagnosing Parkinson's disease through bacterial metagenomic analysis, and more specifically, performing bacterial metagenomic analysis using a sample derived from a subject to analyze the increase or decrease in the content of specific bacterial-derived extracellular vesicles. Thereby diagnosing Parkinson's disease. Extracellular vesicles secreted by microorganisms such as bacteria and archaea existing in the environment are absorbed into the body and distributed to the brain, which can directly affect the inflammatory response and brain function, Since Parkinson's disease is characterized by difficulties in early diagnosis before symptoms appear, efficient treatment is difficult at present, so the metagenome of bacterial extracellular vesicles using a human-derived sample according to the present invention By predicting the risk of developing Parkinson's disease through analysis in advance, the risk group of Parkinson's disease can be diagnosed and predicted at an early stage, and appropriate management can delay the onset of disease or prevent it from occurring. Since an early diagnosis can be made, the incidence of Parkinson's disease can be reduced and the therapeutic effect can be increased. [Selection diagram] FIG.