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Weekly dosing regimens for anti-CD30 vc-PAB-MMAE antibody drug-conjugates
Weekly dosing regimens for anti-CD30 vc-PAB-MMAE antibody drug-conjugates
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机译:抗CD30 VC-PAB-MMAE抗体药物缀合物的每周给药方案
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摘要
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.
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