CONSTRAINED N-SUBSTITUTED TETRAHYDROBENZOAZEPINE SULFONAMIDES AS ANTICANCER AND NEUROPROTECTIVE AGENTS

摘要

A genus of arylsulfonamide derivatives of cyclic constrained tetrabenzoazepines is disclosed. The compounds are of the following genus: (I). The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a therapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.