MEASUREMENT OF BLOOD VOLUME USING FOURIER-TRANSFORM BASED VELOCITY-SELECTIVE PULSE TRAINS ON MRI

摘要

The present invention is directed to a system and method for determining blood volume in a subject. Blood volume is an important hemodynamic parameter for monitoring many disorders, such as stoke and cancer. Current MRI techniques for quantification of absolute blood volume for such clinical applications all require injecting exogenous contrast agents. To reduce associated safety risks and cost, the present invention is directed to a non-contrast-enhanced MRI method for blood volume mapping on MRI. The technique of the present invention employs velocity-selective (VS) pulse trains in paired control and label modules for separating vascular signal by subtraction. The Fourier-transform based VS saturation pulse train (FT-VSS) of the present invention has improved performance over conventional VS pulse trains for the blood volume measurement.