The present invention provides use of an effective amount of genistein phosphate conjugate for the preparation of a composition for treatment or prevention of a disease associated with a decrease in bone mass, wherein the composition is administering to a subject in need of such treatment. The present invention also provides use of the genistein phosphate conjugate for the preparation of a composition for improving bone architecture and bio-mechanical strength of bone. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.
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