METHODS AND COMPOSITIONS RELATED TO IMPROVED FACTOR VIII LONG HALF-LIFE COAGULATION COMPLEXES

摘要

Disclosed herein are methods and compositions related to improved coagulation factor complexes comprising factor VIII with a long half life. Disclosed herein is a coagulation factor complex comprising a factor VIII (FVIII) coagulation factor; a fusion protein comprising a D'D3 domain of von Willebrand's factor fused to full length albumin, or an albumin fragment; and an amino acid linker, in particular a cleavable amino acid linker.