HYBRID THYMUS. METHODS OF MAKING, AND METHODS OF USING TO INDUCE XENOGRAFT TOLERANCE, RESTORE IMMUNOCOMPETENCE AND THYMIC FUNCTION

摘要

The present disclosure relates to making a hybrid pig-human thymic tissue and using the hybrid thymic tissue to induce tolerance in xenotransplantation. The hybrid thymic tissue can also be used for restoring or inducing immunocompetence in a recipient as well as restoring or promoting thymus-dependent ability for T cell progenitors to develop into mature functional T cells in a recipient.