The invention relates to a method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes for identification of an epileptogenic zone in an epileptic patient's brain. This method comprises the steps of - providing a model of the epileptogenic zone and a model of the propagation of an epileptic discharge from said epileptic zone to a propagation zone, and loading said models in a computerized platform personalized according to the patient's brain; - providing at least one hypothesis of the localization of the epileptogenic zone in the patient brain; - for said at least hypothesis of the localization of the epileptogenic zone, simulating, in the personalized computerized patient's brain, epileptic seizures, and determining, for said hypothesis and epileptic seizures, a network of propagation zones; - for a plurality of intracranial implantation schemes of the electroencephalographic electrodes, obtaining, using the personalized computerized patient's brain, simulated electroencephalographic signals activity that is to be measured by the intracranial electrodes implanted according to said plurality of schemes; and - determining, from said plurality of intracranial implantation schemes, an optimized intracranial implantation scheme of the set of electroencephalographic electrodes.
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