Chimeric antigen receptor (car) targeting the chemokine receptor CCR4 and its use

摘要

(A) a scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), which specifically binds to CCR4; (b) hinge and transmembrane domains from CD8; (c) A chimeric antigen receptor comprising an intracellular 4-1BB signaling domain; and (d) a chimeric antigen receptor comprising an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N-terminal to C-terminal order. An antigen receptor is disclosed. Also disclosed are uses of the chimeric antigen receptor, such as for treating malignant tumors.