Amphiphilic block copolymer and its preparation method and nano micellar drug carrier system

摘要

The present invention discloses an amphipathic block copolymer represented by the formula I, a method for preparing the same, and a nanomicelle drug carrier system formed of the copolymer and an insoluble drug. The amphipathic block copolymer contains a hydrophilic chain segment, a hydrophobic chain segment, and a linker connecting the hydrophilic chain segment and the hydrophobic chain segment. The linker contains an unsaturated structure that can enhance the interaction between the insoluble drug and the copolymer, improving the drug loading and stability of the micelles. The present invention further discloses a nanomicelle drug carrier system and methods of its preparation, as well as the use of the nanomicelle drug carrier system in the manufacture of pharmaceuticals for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular and psychiatric disorders. ..