PROTEIN ANTIGEN COMBINATION FOR DETECTING ALZHEIMER'S DISEASE AUTOANTIBODY AND APPLICATION OF PROTEIN ANTIGEN COMBINATION

摘要

A protein antigen combination for detecting an Alzheimer's disease autoantibody in a human serum sample and an application of the protein antigen combination. The antigen combination comprises at least two protein fragments selected from the following proteins: MAPT, ADARB1, P21, DNAJC8, RAGE, ASXL1, and JMJD2D. On the basis of the antigen combination, a kit for diagnosis, especially early diagnosis, of Alzheimer's disease or related risks thereof can be prepared. By using the antigen combination, the early stage Alzheimer's disease can be diagnosed targetedly, rapidly and accurately.