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CAPILLARY ELECTROPHORESIS METHODS FOR VIRAL VECTOR SEPARATION, ANALYSIS, CHARACTERIZATION AND QUANTIFICATION
CAPILLARY ELECTROPHORESIS METHODS FOR VIRAL VECTOR SEPARATION, ANALYSIS, CHARACTERIZATION AND QUANTIFICATION
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机译:病毒载体分离,分析,表征和量化的毛细管电泳方法
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摘要
The disclosure provides methods for analyzing Adeno-Associated Virus (AAV) vectors. More particularly, the disclosure relates to capillary electrophoresis methods for separating, characterizing, and quantifying AAV vectors as having a full length exogenous polynucleotide, having an exogenous polynucleotide fragment, or lacking any exogenous polynucleotide. In one method, the analysis uses capillary isoelectric focusing (cIEF) on a sample comprising viral vectors containing exogenous polynucleotide under conditions and for a duration sufficient to separate the viral vectors based on the isoelectric point (pI) of each viral vector.
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