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- The collection method of diagnosis information of Parkinson's disease by assessment of the -synuclein oligomers in the urine and the kit
- The collection method of diagnosis information of Parkinson's disease by assessment of the -synuclein oligomers in the urine and the kit
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机译:- 通过评估尿液和试剂盒的蛋白核苷酸诊断毒素疾病的诊断方法
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摘要
α-Synuclein (α-Syn) is a major component of Lewy bodies, an important pathological marker of Parkinson's disease (PD). Attempts to use the difference in the amount of α-Syn present in biological fluids such as blood, saliva, and cerebrospinal fluid in PD patients and controls as a diagnostic marker for PD have been in progress for a long time, but the results of these studies were different and there were no practical results. Recently, there has been an attempt to quantify the polymer of α-Syn and use it as a biomarker. The present invention confirmed the presence of α-Syn in concentrated patient urine for the first time, and confirmed the immunoenzyme precipitation method (ELISA) using various α-Syn antibodies that recognize the polymer form of a specific α-Syn. As a result of quantification of specific α-Syn polymers in urine samples of PD patients and controls using this method, the α-syn polymer composed of β-sheet-rich in the urine of patients significantly increased, It was confirmed that the amount of α-syn polymer aggregated in a spherical shape was significantly reduced. In conclusion, it was confirmed that the amount of a specific α-Syn polymer in the urine sample showed a significant difference between the patient and non-patient control groups, and through this, the basis for developing a Parkinson's disease diagnostic kit was derived.
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