,;where R1 is a hydrogen atom or hydroxyl group, R2 is a hydrogen atom or amino group, R3 is a hydrogen atom, halogen atom, hydroxyl group or amino group, R4 is a hydrogen atom, halogen atom or amino group, where R1 and R4 can form a double bound together, R5 is a hydrogen atom or hydroxyl group, R6 is a hydrogen atom, hydroxyl group or amino group, R7 is a hydrogen atom or hydroxyl group, R8 is a hydrogen atom, hydroxyl group or amino group, R9 and R10, each independently, is a hydrogen atom, C1-6alkyl group, amino-C1-6alkyl group, guanidine-C1-6alkyl group, amino-C3-7cycloalkyl group, amino-C3-7cycloalkyl-C1-6alkyl group, amidine group, azetidine group optionally substituted with C1-6alkyl group, glycyl group, sarcozil group, L-alanyl group, D-alanyl group, L-seryl group, D-seryl group, β-alanyl group, L-isoseryl group or D-isoseryl group, and R11 is a hydrogen atom, hydroxyl group or fluorine atom, excluding cases, when (ii) R5, R8, and R11 are hydroxyl groups, R1, R2, R3, R4, R6, R7, R9, and R10 are hydrogen atoms, (iii) R1, R5, R8, and R11 are hydroxyl groups, R2, R3, R4, R6, R7, R9, and R10 are hydrogen atoms, (a) R1 and R4 form a double bound together, R5, R8, and R11 are hydroxyl groups, and R2, R3, R6, R7, R9, and R10 are hydrogen atoms, (b) R1 and R4 form a double bound together, R8 and R11 are hydroxyl groups, and R2, R3, R5, R6, R7, R9, and R10 are hydrogen atoms, (c) R1, R2, R3, R4, R5, R6, R7, R9, and R10 are hydrogen atoms, and R8 and R11 are hydroxyl groups.;EFFECT: obtaining new effective aminoglycoside antibiotic against multidrug-resistant bacteria.;14 cl, 6 tbl, 86 ex"/>
NEW EFFECTIVE AMINOGLYCOSIDE ANTIBIOTIC AGAINST MULTIDRUG-RESISTANT BACTERIA
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NEW EFFECTIVE AMINOGLYCOSIDE ANTIBIOTIC AGAINST MULTIDRUG-RESISTANT BACTERIA
NEW EFFECTIVE AMINOGLYCOSIDE ANTIBIOTIC AGAINST MULTIDRUG-RESISTANT BACTERIA
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机译：针对多药抗性细菌的新有效氨基糖苷类抗生素
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FIELD: pharmaceutics.;SUBSTANCE: present invention relates to a compound represented by the general formula (I), or to its pharmaceutically accepted salt that have antibacterial activity, to a pharmaceutical composition based on them, an antibacterial agent, to use of the claimed compounds and method for preventing or treating bacterial infectious disease. ; ,;where R1 is a hydrogen atom or hydroxyl group, R2 is a hydrogen atom or amino group, R3 is a hydrogen atom, halogen atom, hydroxyl group or amino group, R4 is a hydrogen atom, halogen atom or amino group, where R1 and R4 can form a double bound together, R5 is a hydrogen atom or hydroxyl group, R6 is a hydrogen atom, hydroxyl group or amino group, R7 is a hydrogen atom or hydroxyl group, R8 is a hydrogen atom, hydroxyl group or amino group, R9 and R10, each independently, is a hydrogen atom, C1-6alkyl group, amino-C1-6alkyl group, guanidine-C1-6alkyl group, amino-C3-7cycloalkyl group, amino-C3-7cycloalkyl-C1-6alkyl group, amidine group, azetidine group optionally substituted with C1-6alkyl group, glycyl group, sarcozil group, L-alanyl group, D-alanyl group, L-seryl group, D-seryl group, β-alanyl group, L-isoseryl group or D-isoseryl group, and R11 is a hydrogen atom, hydroxyl group or fluorine atom, excluding cases, when (ii) R5, R8, and R11 are hydroxyl groups, R1, R2, R3, R4, R6, R7, R9, and R10 are hydrogen atoms, (iii) R1, R5, R8, and R11 are hydroxyl groups, R2, R3, R4, R6, R7, R9, and R10 are hydrogen atoms, (a) R1 and R4 form a double bound together, R5, R8, and R11 are hydroxyl groups, and R2, R3, R6, R7, R9, and R10 are hydrogen atoms, (b) R1 and R4 form a double bound together, R8 and R11 are hydroxyl groups, and R2, R3, R5, R6, R7, R9, and R10 are hydrogen atoms, (c) R1, R2, R3, R4, R5, R6, R7, R9, and R10 are hydrogen atoms, and R8 and R11 are hydroxyl groups.;EFFECT: obtaining new effective aminoglycoside antibiotic against multidrug-resistant bacteria.;14 cl, 6 tbl, 86 ex
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